Long-term efficacy of omalizumab in patients with conventional treatment-resistant vernal keratoconjunctivitis

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Omalizumab. An option in vernal keratoconjunctivitis?

Vernal keratoconjunctivitis (VKC) is a severe ocular disease with immediate and delayed hypersensitivity reactions which can produce loss of visual acuity and blindness. In its physiopathology a Th1 and Th2 response is present and the therapeutic approach is very difficult because the use of local immunosuppressive therapy such as topical corticosteroids for a long time could produce severe adv...

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Long-term efficacy of omalizumab in seven patients with treatment-resistant chronic spontaneous urticaria.

BACKGROUND Monoclonal anti-IgE antibody omalizumab is a promising therapeutic option in patients with chronic urticaria (CU) resistant to non-sedating H1-antihistamines (nsAH). However, data about its long-term efficacy and safety are still scant. OBJECTIVE We retrospectively analysed the clinical course of patients with severe recalcitrant CU that were treated in our department with omalizum...

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Immunological characteristics of patients with vernal keratoconjunctivitis.

PURPOSE Previously, we have reported that local excision and immunosuppressive treatment are useful in treating patients with very severe vernal keratoconjunctivitis (VKC). METHODS We measured serum levels of immunoglobulins, cytokines, and interleukin-2 receptors (IL-2R) and the concentration of IL-4 in tears of 10 patients with severe VKC, and made a comparison with data from 10 healthy con...

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Vernal keratoconjunctivitis

Vernal keratoconjunctivitis (VKC) is a chronic allergic conjunctivitis that is most often seen in young, males. Although most types of allergic conjunctivitis do not affect vision, VKC is unusual in that damage to the cornea from the condition can result in vision loss. Although it is typically seasonal, year-round symptoms can be seen, which can lead to uncertain diagnoses being made. Although...

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ژورنال

عنوان ژورنال: Revista Alergia México

سال: 2018

ISSN: 2448-9190,0002-5151

DOI: 10.29262/ram.v65i2.292